You are clogging your wineprefix pretty much with lots of unneeded stuff. You should always try keep it clean as possible, and for games that need lots of overrides you should do a new prefix.
Second, make sure you are actually using kernel with smaller latency (such as the mainline -rt patchset or -ck (with BFS scheduler)), if you are going to run multimedia applications. However, only if you care about performance. If you have pulseaudio, disable it and use OSS/ALSA instead. Pulseaudio gives major stress for CPU and introduces latency.
The GLSL disabling is only for nvidia cards(not actually disabling GLSL, but using ARB extensions), for other cards it does disable however and bad things happen. But if you are going to use Wine, you should not use anything else than nvidia anyways.
http://wiki.winehq.org/UsefulRegistryKeys
Also if you are using Ubuntu(or any variant with outdated packages and shitloads of daemons running), ditch it.
Just some tips, I guess.
As pointed out, if you want to save from hassle. Boot to Windows or play from console.
Video how Skyrim runs under my crappy desktop:
https://www.youtube.com/embed/rfqsR9NF5R0?feature=oembed
The kernel differences make me wonder though, if Pandora is actually running "default" kernel,
without any patch sets reducing latency for multimedia computing.