Overall impression
+ Gambatte's graphics (proper vsync, excellent scalings filters, particularly hqx3, custom palettes for bg/sprite1/sprite1) & sound (hi qual filters!) abilities are superior to my previous favorite GameBoy emulator GnGB.
- Gambatte's usability is inferior to GnGB, as it has no overlay/in-place menus, which are easily accessible by gaming buttons (GnGB, PCSX, etc) but instead a ordinary desktop menu bar (bad usability for gaming app).
If it's possible to build a custom menu system, then I'd say take PCSX as a model, its menu has excellent usability. If not, then there some quick wins are at least possible:
Feature suggestion: ESC shall activate menu focus right away
Currently you need to press ESC, then ALT to get focus into the menu.
Inquiry: Is it possible to assign keystrokes to these?
Select next color palette
Select color palette X
Select next video filter
Select video filter X
Select next sound-quality
Select sound quality X
Having the trouble to navigate to the menu, then within the menu through the whole hierarchy is a PITA for a quick change.
Having keystrokes would solve the issue mostly.