Slower by milliseconds, perhaps. Human response time is measured in tenths of seconds, easily 100 times the amount of delay from bluetooth communication. If the extra .001 second is your make-or-break, I suggest you are a mutant with superhuman reflexes and should therefore be able to compensate accordingly.
Incidentally, PS3 and Wii controllers are both bluetooth and the XBox360 is some kind of modified bluetooth (if I understand correctly) so they all experience the exact same "lag" and I don't hear anyone complaining about those.