Fn+Q, with Fn bottom right and Q almost top left, if you dont use shoulders, ties up your hands at almost the worst imaginable position.
It is not a place where escape should be, since it isn't expected.
Along with this, makes it a
usability error:
It is in a place where if you try to write a - you are one button away from missing it, and accidental ESC.
It is in a place where if you try to do F1 you are one button away from missing it, and accidental ESC.
It is in a place where if you try to do F2 you are one button away from missing it, and accidental ESC.
It is in a place where if you try to do { you are one button away from missing it, and accidental ESC. (this kills the coding)
It is a place where if you try to write a big Q, you are one button away from missing shift, and accidental ESC.
Ctrl+Esc is a IBM-compatible shortcut for bringing up the menu. If both ctrl and esc is not to be found in an expected position, that is worse, if used by shoulders, it requires an extra shoulder.
On chromebooks, (which have no super) it brings up the task manager with
shift+esc.
It also makes the otherwise possible combo, Fn+Esc, or Fn+Q if you like to think of it that way into just Esc, so less possibility there.