My PC is midrange (from 2008, even then it was just getting superseded), it runs all the PS2 games I've thrown at it pretty well (to be fair, it's a small amount of games that I have). Plus, that was an old version from probably 2 or 3 years ago. I'd imagine with a high-end PC today, plus the newest version of PCSX2 (just checked--they just released 1.0!), most games should be quite playable!