Not that I can recall. There's a plan to make the internal µSD card available at the same time as the eMMC that's still only on paper, but that consequently hasn't actually blocked anything. The biggest problem was getting all the voltages right so that the 4 1GB RAM chips would work properly, but I don't think there was ever a big problem getting the SD slots wired. AFAIK all SD cards are still 8bit devices, so they don't take up all that much space on a big board like the Pyra's (apart from the physical footprint, which may have pushed some bits and pieces around I guess).