Meh. Pandora's screen is 4.3" diagonally, which should mean (800 * x)^2 + (480 * x)^2 = 18.49, 870400 x^2 = 18.49, making pixels 0.004609 square inches in size, and the width of the screen 3.6872 inches and the height 2.2123 inches.
The Nintendo DS screens are 3 inches diagonally, 256x192, so (256 * x)^2 + (192 * x)^2 = 9, 102400x^2 = 9, making pixels 0.009375 square inches in size, and the width of the screen 2.4 inches and the height 1.8 inches.
Direct comparison of sizes with different configurations:
Main screen 512x384, sub screen 256x192 - main screen is 2.359808 inches by 1.769856 inches, making it just slightly smaller than the DS screen physically. Subscreen is 1/4th that area, but a lot of DS games favor one screen over the other in levels of content importance - ones that rely on the stylus usually do it on the "important" screen as well.
Main screen and sub screen both 400x300, side by side - scaling causes some blur/loss of contrast but nothing horrible (GBA on PSP doesn't look particularly bad). Both are 1.8436 inches by 1.3827 inches, 2.54914572 square inches surface area, which is about 59% of the surface area of the DS's screens. However, if you compare this to the GB Micro's 2" screen you will see that it's about 138% the surface area. Since there are people who are willing to use GB Micro then I can only imagine there'd be people willing to use this setup.
Main screen and sub screen 320x240 on top of each other - scaling again. This is the worst configuration, but only necessary for a small number of games that align the screens continuously.
These configurations would be sufficient for so many people for so many games that throwing them out just because Pandora doesn't have two screens is very short sighted.