Only is they used buttons on the edge of the keyboard. Admittedly, L might cause some issues for load, but S is far enough in not to make a difference.
As long as features like that used arbitrary letters near the centre of the keyboard (G, T, or something) then there'd be no issues. Similarly, if a key combo of L+number/S+Number was used, no issues; you can't easily hit the numkeys by mistake...