I ran it on mine, thought it was pretty cool. Didn't really have any problems with it and I'd never played Transport Tycoon before I played it on my GP2X. Quite enjoyed it but the virtual window thing (you see a quarter of the screen and you press a key combination to change which corner) was pretty annoying. Especially when you went to one screen to open the build whatever window and then have to hunt around for where the window opened up.
Hope the guy continues working on it, it's a really nice little game.
Got quite far on it but gave up in the end when my GP2X's batteries died and I hadn't saved for ages. Now I think of it, there was probably an autosave. Oh well. Can't wait for GPH to get that battery light sorted, it's really annoying.