Well, this thread just goes to show there are no right answers as far as control layout / user interface matters are concerned. Only that everyone else is wrong!
Our best hopes are that the device is easily configurable.
For what it is worth, this would be my preferred method of mouse input :
Left Nub : Scrolling horizontal and vertical - This will be useful with a low res device
Right Nub : Move mouse - I'm right handed, I use my right hand to move the mouse.
Left Shoulder : Left Click - Click twice for double click
Right Shoulder : Right Click
Left & Right Shoulder : Centre Click
Looking forward to playing around with various control set ups, these configuration scripts seem like the making of a truly flexible system, as with the videos, keep 'em coming.