"Edit: Old rom set v.34 from Gp2x also works fine. If your mostly using the 2xscale version then place your roms in that 'appdata>mame2x.106' folder and they are listed by default, then use normal Mame and browse to their for games that don't fit the screen, or use rotation instead."
Un-official advice follows...
I don't know if this is any help but I found zero issues on first attempt with Mame, in the following folder structure, using Roms from a way earlier v.77 rom set.
Sd>card>pandora>appdata (make sure you have created this folder first)
Then:
Sd card>pandora>menu (Place Mame .PND here)
The menu and minimenu will offer you two versions in the emulator list or 2 icons, one with "2xScale"
Run Both versions and quit them to create folders in the appdata folder respective, to each Mame version.
Roms go in:
Sd card>pandora>appdata>mame.106>roms (in zipped format).
As Prometheus mentions, be sure to include either the parent rom, or all related zips of any game you intend. For example
aliens.zip plus none is fine, as it's the parent rom,
3wonders.zip also but
3wonderu.zip alone, will do nothing.
Sometimes you may want the regional version difference, so
Exciting Hour 'UK'(excthour.zip) requires
MatMania 'US' (matmania.zip) to work with the regional differences (A bone crunchingly slapstick wrestling game worth a gander btw!). With some roms though, they wont work with the 2xscale version due to resolution, such as
Matmania, so try launching from either.
Navigate to the roms, via
SD card>pandora>appdata>mame.106>roms and then launch.
Works from either Mame version but is quite a browse. I acknowledge I've probably set this up all wrong (hence the long file browse to roms) but it works well, with only minor sound issues on some games for many I have tried, so perhaps its worth trying if your doing differently without success!
I will test with an even older romset from GP2x days v36 or something, in a moment and post back, as I doubt the Rom set age will matter, providing it is lower.
Hope that helps:
Fn-swoosh (TAB)to get the menu and remap the keys, as the right nub seems defaulted to the P1 fire buttons and I cant get any changes to save it globally, or per game, with any lasting memory on re-playing. Any ideas?
Doh...I'm way to late as usual hence the name! Is there a better lay-out to try btw?