What kind of speed do you get with a USB reader with a class 6 SD card? My 16GB Transcend card, class 6, maxes out USB at around 24 MB/s. I say max out because my external HD does 24 MB/s on any computers through USB but the same drive on eSATA is 60 MB/s on every computer I've tried so I think my SD card maxes USB out.
Anyway, from my experience the bottle neck of the speed of anything is USB 2.0, never the actual device (hard drive, SDHC, thumb drive). So if you plan to use USB on the Pandora you're capped at USB 2.0, pretty much every class 6 card maxes that out. On this
wiki page it caps the fastest SDHC card at 45 MB/s, way faster than my experiences with USB. This
wiki page on USB says the 2.0 spec is up to 60 MB/s, I've never seen that though.
Just for fun I ordered this
this to see if I can get over 24 MB/s with my card. I also want a card reader in my computer permanently and I can mod this nice into my floppy port, I already have all the front ports so I didn't really need one of those all in one drive bay things.
Anyway, speed shouldn't be that big of a concern, the only time you really need speed is when you move data from one card to another or put it into your computer to load games/music/movies. I kinda get annoyed when I go to load 10+ gigs on my SD card for my GP2X, thinking I should be getting more than the USB bottle neck, but patience is a virtue.
Storage capacity is a concern though, 64GB is what the ipod touch has right now so the potential of the Pandora is on par with current solid state devices. in X amount of years the Pandora 2 will come out and I'm sure it will have the current card storage technology, so I'm fine with the limitations of SDHC for now.